Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes

Summary: Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a).This mark has been reported to associate with silent genes.Here, we use a cell model of neural differentiation, which upon PRMT6 knockout exhibits proliferation and differentiation defects.Strikingly, we detect PRMT6-depen

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Rapidly progressive neovascular glaucoma following coronary artery bypass graft surgery in a patient with type 1 diabetes mellitus: a case report

Abstract Background Proliferative diabetic retinopathy leading to vitreous hemorrhage, tractional retinal detachment, and neovascular glaucoma is a major cause of CORDLESS T-OUTLINER TRIMMER severe sight impairment in adults of working age worldwide.Neovascular glaucoma occurs in 2.5% of patients with proliferative diabetic retinopathy, which is di

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